Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival

JMN Lopes Cardozo; IL Andrulis; SE Bojesen; T Dörk; DM Eccles; PA Fasching; MJ Hooning; R Keeman; H Nevanlinna; EJT Rutgers; DF Easton; P Hall; PDP Pharoah; LJ Van 't Veer; MK Schmidt; TU Ahearn; H Anton-Culver; V Arndt; PL Auer; A Augustinsson; LE Beane Freeman; H Becher; MW Beckmann; S Behrens; J Benitez; M Bermisheva; C Blomqvist; MK Bolla; B Bonanni; T Boyle; H Brenner; SY Brucker; T Brüning; B Burwinkel; SS Buys; NJ Camp; F Canzian; F Cardoso; JE Castelao; MH Cessna; TL Chan; J Chang-Claude; G Chenevix-Trench; JY Choi; SV Colonna; E Copson; FJ Couch; A Cox; SS Cross; K Czene; MB Daly; J Dennis; P Devilee; CA Drukker; AM Dunning; M Dwek; AH Eliassen; C Engel; DG Evans; JD Figueroa; O Fletcher; H Flyger; M Gago-Dominguez; M García-Closas; JA García-Sáenz; J Genkinger; GG Giles; A González-Neira; P Guénel; M Gündert; E Hahnen; CA Haiman; N Håkansson; U Hamann; M Hartman; BAM Heemskerk-Gerritsen; A Hein; WK Ho; R Hoppe; JL Hopper; RS Houlston; A Howell; DJ Hunter; H Ito; A Jakubowska; H Jernström; EM John; N Johnson; ME Jones; V Joseph; R Kaaks; D Kang; SW Kim; CM Kitahara; LB Koppert; VM Kosma; P Kraft; VN Kristensen; K Kubelka-Sabit; S Koutros

Journal article

Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival

JMN Lopes Cardozo, IL Andrulis, SE Bojesen, T Dörk, DM Eccles, PA Fasching, MJ Hooning, R Keeman, H Nevanlinna, EJT Rutgers, DF Easton, P Hall, PDP Pharoah, LJ Van 't Veer, MK Schmidt, TU Ahearn, H Anton-Culver, V Arndt, PL Auer, A Augustinsson Show all

Journal of Clinical Oncology | American Society of Clinical Oncology (ASCO) | Published : 2023

DOI: 10.1200/JCO.22.01978

Abstract

PURPOSEA polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer.METHODSWomen with invasive breast cancer were included, 98,397 of European ancestry and 12,920 of Asian ancestry, from the Breast Cancer Association Consortium (BCAC), and 683 women from the European MINDACT trial. Associations between PRS313 and clinicopathologic characteristics, including the 70-gene signature for MINDACT, were evaluated using logistic regression analyses. Associations of PRS31..

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